Abstract: [Purpose/Significance] In order to gain a confrontational advantage, this study make an in-depth exploration and optimization of the path of the development of China’s scientific and technological information on the basis of grasping the strategic trend of the USA’s technological competition with China. [Design/Methodology] Through online research and content analysis, this article sorted out the implementation and research trends of the Biden administration and related think tank’s technology competition strategy against China, and summarized the main characteristics of their strategies. An intelligence empowerment model was also constructed to deal with China-related technology competition strategies. Finally, it proposed the construction of intelligence empowerment path for China’s science and technology information industry to face more competition from major powers. [Findings/Conclusion] Facing the scientific and technological competition from big countries, China’s science and technology information education needs to adhere to the concept of parallel innovation and development, and enrich the training mode of intelligence talents;The theoretical research of scientific and technological information needs to realize the theoretical innovation of multi-disciplinary integration;the scientific and technological information work also needs to improve the strategic positioning, strengthen the construction of the information service platform, and form a symbiotic, coexisting and co-progressive ecological intelligence system capability system. [Originality/Value] Based on the latest strategic trends of the USA’s science and technology competition against China, and the theoretical basis of intelligence empowering national science and technology security and innovation development, this paper proposed a construction path for intelligence empowerment facing the science and technology competition from major powers. It also provides the corresponding construction basis for the future innovation and development of China’s national science and technology strategy.

Key words: Intelligence empowerment, Scientific and technological information, Scientific and technological competition strategy; , Technology alliance, Technology life cycle