Abstract: [Purpose/Significance] Artificial Intelligence（AI）as a significant technological form leading future development, not only promotes socio-economic progress and stimulates industrial innovation, but also raises new issues about whether AI will replace human labor. It is necessary to pay attention to the substitution effect of technological advancement represented by AI on Library and Information Science（LIS）practitioners and the new demands for skills and knowledge. [Design/Methodology] Using the O*NET database, this study predicts the probability of LIS occupations being replaced by AI based on machine learning and network analysis methods. It identifies the important professional skills, core knowledge, and core competencies required by related positions, and explores the skill advantages of human intelligence in engaging in LIS occupations. [Findings/Conclusion] Under the impact of AI, library clerical assistants and library technicians, etc., whose jobs are programmable, face the risk of being replaced in the short term. In this macro environment, LIS professionals are required to possess both technical and humanistic qualities. The skill advantages of human intelligence in LIS professionals are mainly reflected in their creativity, social interaction, management planning, and proactive learning. [Originality/Value] Objectively examining the issue of labor substitution  brought about by AI, predicting and evaluating the probability of AI completely replacing LIS professions, and identifying the core abilities that LIS professionals should develop, can help actively respond to technological unemployment in the era of artificial intelligence, and ensure stable employment in LIS.

Key words: Artificial intelligence, LIS occupations, Displacement effect, Core knowledge, Core literacy