Abstract: ［Purpose/Significance］This paper intends to explore the measures and approaches of cross-disciplinary and cross-institutional knowledge consilience for multi-sourcing cultural heritage materials of Gallaries, Libraries, Archives, Museums(GLAM) as cultural memory institutions.［Design/Methodology］Based upon the "Metadata Application Profile", the concept of "Ontology Application Profile" was proposed. Taking the extension of Shanghai Library’s manuscript archives as an example, which was converted from "Metadata Application Profile" to "Ontology Application Profile", the principle, method and process of "Ontology Application Profile" design were illustrated. The integrated ontology and its knowledge consilience model were developed based upon the historical and humanistic data infrastructure. Moreover, the method of cross-domain knowledge consilience based on the extension with the use of "Ontology Application Profile" was verified.［Findings/Conclusion］Metadata application profiles provide structured data as foundation for knowledge consilience of cultural heritage materials. At the same time, ontology application profiles take into account the specific needs of special types of resources, and the knowledge consilience model of integrated ontology is used to ensure the unity of knowledge modeling and the consistency of knowledge representation.
［Originality/Value］When combined with the technologies of linked data and knowledge graph, the integrated ontology design based on multiple ontology application profiles is deemed as a new organization method of knowledge, which could provide  a method and path for cross-institutional and interdisciplinary knowledge consilience.

Keywords: Ontology Application Profile, Knowledge consilience, Cultural memory, Digital Humanities, Data infrastructure